A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids
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چکیده
منابع مشابه
A CDKN2-like polymorphism in Xiphophorus LG V is associated with UV-B-induced melanoma formation in platyfish-swordtail hybrids.
The genetic basis of spontaneous melanoma formation in spotted dorsal (Sd) Xiphophorus platyfish-swordtail hybrids has been studied for decades, and is adequately explained by a two-gene inheritance model involving a sex-linked oncogene, Xmrk, and an autosomal tumor suppressor, DIFF. The Xmrk oncogene encodes a receptor tyrosine kinase related to EGFR; the nature of the DIFF tumor suppressor ge...
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Sunlight exposure is strongly indicated as one of the important etiologic agents in human cutaneous malignant melanoma. However, because of the absence of good animal models, it has not been possible to estimate the wavelengths or wavelength regions involved. We have developed a useful animal model from crosses and backcrosses of platyfish (Xiphophorus maculatus) and swordtails (Xiphophorus hel...
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Xiphophorus cortezi males are polymorphic for the pigment pattern vertical bars. In this study, we determined whether X. cortezi females are polymorphic in their preference for this trait by examining both withinand between-individual variation in female preference. There was significantly more variation in female preference within than between individuals using both video animations and live m...
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The forces responsible for maintaining genetic polymorphisms within populations are often unclear. Male pygmy swordtails are polymorphic at a single Y-linked locus that regulates body colour. The visually conspicuous, sex-limited polymorphism suggests that sexual selection is important for maintaining genetic variation for these conspicuous phenotypes. We performed a series of behavioural exper...
متن کاملEstablishment of a cell line from the platyfish-swordtail hybrid melanoma.
A fish melanoma cell line, PSM-1, was established from a hereditary melanoma in an interspecific hybrid of Xiphophorus for cytogenetic studies of this melanoma system. An amelanotic melanoma was obtained from the tail fin of a melanotic F1 hybrid between a spotted platyfish (Xiphophorus maculatus) and an albino swordtail (Xiphophorus helleri). The tumor tissue was dissociated and cultured in Ea...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1996
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.93.23.13042